Researchers have developed a new technology that improves the precision and integration density of synthetic genetic circuits.

Data demonstrate engineered tRNA from company’s first development candidate restores protein production to clinically meaningful levels in two disease models driven by the same premature termination ...

One of the post-transcriptional modifications, Ψ, is widespread in RNAs, particularly in long non-coding RNA (lncRNA), where it enhances the activity of tRNA and rRNA by fortifying the structure of ...

While both the tRNA system and ribozyme system performed well in rice, their effectiveness varied in wheat and barley. Specifically, the tRNA system outperformed the ribozyme system, achieving higher ...

By contrast, the ribosomal decoding centre is considered ‘blind’ to mischarged tRNAs since these have cognate codon•anti-codon pairing ... could better discriminate against misacylated-tRNA. The ...

Badran’s team investigated how codon location and usage affect quadruplet decoding ... serving as a location guide for plugging in engineered tRNAs. During tRNA development, the researchers identified ...

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, USA Department of Brain and Cognitive Sciences, Massachusetts Institute of ...

This seminar series brings together researchers from around the globe who study neurodegenerative diseases and age-related neurodegeneration using flies. The fruit fly Drosophila is an incredibly ...