Oncogenic YAP accelerates S-phase entry by shortening G1, leading to replication stress and sensitivity to CHK1 inhibition.

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's ...

Mechanistic discrepancies between species highlights the limitations of mouse models in advancing STING inhibition drugs for various diseases.

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against cancer. This pathway, which plays a key role in ...

In retrospect, it is hard to say definitively whether Rani Padmini's continuing fame stems more from her movies or from the ...

SGR-1505 was designed using Schrödinger's computational platform at scale and was discovered approximately 10 months after the company started its MALT1 program. A Phase 1 study in patients with ...

According to a recently published study, cannabis sugar leaves demonstrate promising antimicrobial effects against several ...

The misunderstood story of Phineas Gage shows that we need a new way of understanding the experiences of brain injury ...

This is a valuable and rigorous study that addresses the question of what determines the spatial organization of endocytic zones at synapses. The authors use compelling approaches, in both Drosophila ...

(NASDAQ: ONC; HKEX: 06160; SSE: 688235), a global oncology company, today announced that the U.S. Food and Drug Administration (FDA) has approved a new tablet formulation of BRUKINSA ® (zanubrutinib) ...

Meanwhile, when the researchers prevented this decrease in inhibition, the animals failed to learn. "We were surprised that PVs decreased their firing as animals approach a learned reward zone ...

Rodent medial prefrontal cortex is not crucial for an active place avoidance task requiring cognitive control evidenced by hippocampal activity that purposefully alternates between task-relevant and ...