High uric acid often presents subtle symptoms beyond joint pain. Not every symptom speaks in a loud voice. Sometimes, it ...

The buildup of uric acid in your joints can lead to swollen growths under your skin called tophi. If left untreated, tophi can lead to loss of motion in your joints and other complications.

Diagnosis CT showed no internal derangement, but revealed extensive intra-articular and extra-articular amorphous soft tissue calcifications, compatible with gouty tophi. Management The patient ...

In the final stage, large crystals called tophi can cause joint damage and structural changes. Read on to learn more about the four stages of gout. Gout progresses through four stages. With proper ...

She also had numerous small subcutaneous tophi in her hands. The patient was intolerant to allopurinol and had mild renal insufficiency attributed to uric-acid nephrolithiasis and interstitial ...

Pegloticase quickly resolved tophi among patients with gout who responded to the treatment, according to data published in Arthritis Research & Therapy. “Pegloticase is a recombinant mammalian ...

The present study quantifies the impact of the presence of tophi and frequency of acute gout attacks on health-related quality of life (HRQOL), productivity, and healthcare resource utilization.

gout of foot The investigational drug AR882 appeared more effective and safer than allopurinol monotherapy in a phase 2 trial. A novel selective URAT1 inhibitor, AR882, further reduces serum uric ...

If crystals build up under the skin, and form small white or yellow lumps known as tophi - caused by tophaceous gout - it can be a sign the condition is serious. NHS Choices said: “Tophi are ...

The primary endpoint is reduction of sUA by month six. Secondary endpoints include a reduction in flare and tophi over time. The trial is expected to be fully enrolled in 2025 and completed by the ...

The objective of the present study was to better understand the burden associated with signs and symptoms of gout (namely, tophi and flares) in larger, more diverse, and more representative ...