More information: Abstract no: 12, "On-target mutations drive resistance to WRN helicase inhibitors in microsatellite ...

Although pembrolizumab is approved for deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors regardless of histology, there is a paucity of data to support its effectiveness ...

Microsatellite instability (MSI) is a “striking” prognostic factor for patients with gastric cancer, even after controlling for clinicopathologic characteristics, according to researchers. The ...

What Is a Brain Tumor? A brain tumor (also called an intracranial tumor) is a cluster of abnormal cells that grows in or around your brain. There are over a hundred types of tumors that develop in ...

The ability to detect serrated polyps by fecal blood testing, computed tomographic (CT) colonography and colonoscopy is limited. Serrated polyps are less likely than adenomas to bleed, so fecal ...

The FDA recently approved a phase 2 clinical trial to investigate the efficacy of leronlimab in patients with relapsed or ...

Nimbus Therapeutics LLC reported the identification of an allosteric, potent, selective, highly efficacious and noncovalent Werner syndrome helicase (WRN) inhibitor, NTX-452, for the potential ...

The strategy, which they demonstrated in cells in the lab, forces brain cancer cells to display targets for the immune system to ... Researchers Home in on Tumor Vulnerabilities to Improve Odds of ...

This game-changing tool is helping cancer researchers and doctors save lives. Bioinformatics professor Jeroen de Ridder (at left) and molecular pathologist Bastiaan Tops developed AI that ...

Oct. 30, 2024 — A new analysis has revealed detailed 3D maps of the internal structures of multiple tumor types. These cancer atlases reveal how different tumor cells -- and the cells of a tumor ...

Thyroid cancer is a type of cancer that starts in your thyroid gland. A gland is an organ in your body that makes a substance. Your thyroid is shaped like a small butterfly and is found inside the ...

(ends) Abstract no: 12, “On-target mutations drive resistance to WRN helicase inhibitors in microsatellite unstable colorectal cancer”, by Gabriele Picco, presented in plenary session 7 ...