Semiconservative replication was not the only model ... DNA unwinding at a single spot on the chromosome known as the replication origin. As the double helix unwinds, it creates a loop known ...

DNA replication is happening continuously throughout the body, as many as trillions of times per day. Whenever a cell divides ...

The illustration shows DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). The purple part of the motor (with a red/green label) is the protein subunit NIPBL, which acts ...

However, SMC machines don't naturally know which parts to connect. They simply load somewhere on the DNA and start shaping it into a loop until they reach a point where they are forced to stop. That's ...