Intriguingly, the two cyclic peptides not only tolerate Gβγ while inhibiting Gα, but even actively promote the PPI between the inhibited Gα and Gβγ through direct engagement of R96/D118:Gβ. Because ...

State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ...

To overcome these limitations, researchers are developing novel peptides with enhanced antibacterial properties and reduced side effects. These efforts focus on modifying naturally occurring AMP ...

AMPs cyclization, glycosylation ... Some more prominent antiviral AMPs include defensin, LL-37, tensin, cyclic peptide, and lactoferrin. LL-37 has been reported to inhibit viruses such as human ...

Gansu Provincial Key Laboratory of Environmental Oncology, Department of Tumor Center, Lanzhou University Second Hospital, Second Clinical Medical School, Lanzhou University, Lanzhou 730000, China ...