Intriguingly, the two cyclic peptides not only tolerate Gβγ while inhibiting Gα, but even actively promote the PPI between the inhibited Gα and Gβγ through direct engagement of R96/D118:Gβ. Because ...

Peptides are smaller versions of proteins. They may provide pro-aging support, anti-inflammatory, or muscle-building properties. However, more research is still necessary to understand their risks ...

AMPs cyclization, glycosylation ... Some more prominent antiviral AMPs include defensin, LL-37, tensin, cyclic peptide, and lactoferrin. LL-37 has been reported to inhibit viruses such as human ...

Gansu Provincial Key Laboratory of Environmental Oncology, Department of Tumor Center, Lanzhou University Second Hospital, Second Clinical Medical School, Lanzhou University, Lanzhou 730000, China ...

Biosystems and Integrative Sciences Institute, Faculdade de Ciências da Universidade de Lisboa, Edifício C8, Campo Grande, 1749-016 Lisboa, Portugal ...

This method is efficient for protein-protein or protein-peptide fusions at the N- or C-termini. It enables the generation of defined and completely labeled antibody conjugates with one fusion partner ...

A and B symbolize peptides or proteins. Figure 2: Mutagenic analysis of the Connectase recognition sequence. A ubiquitin substrate with a C-terminal Connectase recognition sequence followed by a ...

In this work, we report novel cyclic peptides harboring the RKD motif in the ISM AMOP domain that function as proapoptotic ligands of cell-surface GRP78. The most potent peptide, BC71, binds to GRP78 ...

Then, the cyclic pentapeptide cyclo (Arg-Gly-Asp-D-Phe-Val) (denoted as cyclic RGD peptide) was prepared and found to be ... During the optimization of radiotracers, strategies such as cyclization, ...