One of the most widely used tools for assessing and communicating scientific uncertainty is Grading of Recommendations Assessment, Development, and Evaluation (GRADE), a system for rating the quality ...

Healthcare delivery is being transformed by the rapid growth of data, advancements in artificial intelligence (AI) and other ...

Objectives Over the last two decades, the incidence of endometrial cancer has risen by 55% whilst its mortality has been stable.1 These trends have raised concerns that the increase in the incidence ...

Objective The objectives of this scoping review were to provide an overview of existing guidelines for the development and validation of patient-reported outcome measures (PROMs), review them for ...

Registration of health and medical research is an effective way of improving the transparency and credibility of evidence. Registration involves pre-specifying the research objectives, design, methods ...

Scientific progress requires transparency and openness. The ability to critique, replicate and implement scientific findings depends on the transparency of the study design and methods, and the open ...

What it is Overdetection refers to the identification of abnormalities that were never going to cause harm, abnormalities that do not progress, that progress too slowly to cause symptoms or harm ...

In addition to reducing patient harms and wasted resources, efforts to reduce low-value care produce significant climate and population health benefits, but these benefits are typically not elucidated ...

Understanding the causes of deaths and how they can be prevented is critical for improving healthcare outcomes. At a population level, over-reporting or under-reporting of deaths can have a profound ...