Late in the second quarter, as Tampa Bay's offense was advancing down the field, Wirfs' right knee was caught under a San Francisco defensive lineman. After briefly staying down on the ground, the star left tackle was assisted by trainers as he limped off the field, unable to put any weight on his right leg.

The early belief is that Buccaneers left tackle Tristan Wirfs suffered an MCL sprain on Sunday, a source told ESPN's Jeremy Fowler.

Buccaneers left tackle Tristan Wirfs exited their game with the San Francisco 49ers with an apparent knee injury and is questionable to return. A Niners defender was blocked into Wirfs' knee while he was blocking defensive end Nick Bosa.