To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting ...

Adhesive Interactions Influencing Metastases Integrins are the major extracellular matrix (ECM) receptors ... of the various elements of the tumor microenvironment or targeting signaling pathways ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting ...

Tumor microenvironment (TME) plays a pivotal role in malignant progression and metastatization in several tumors, including ...

Tumor cells undergoing epithelial–mesenchymal transition (EMT) can profoundly modulate their microenvironment via enhanced secretion of multiple soluble factors, including IL-8, IL-6 ...

Given the fibrotic nature of the scars, they reasoned that extracellular matrix (ECM) proteins would be prominent ... that really allowed us to identify the key networks within the tumor ...

Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are capable of degrading almost all protein components of the extracellular matrix (ECM). MMPs have garnered attention as ...

More information: Tancredi Massimo Pentimalli et al, Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironment, Cell Systems (2025).

fueled a myeloid-rich tumor microenvironment in mice, and resulted in the promotion of tumor organoid growth. TI-CH increased the risk of disease recurrence or death among patients with NSCLC and ...