19 ligands and 29 receptors that belong to the tumour-necrosis factor (TNF) superfamily have been identified. At the cellular level TNF-superfamily members promote either apoptosis, proliferation ...

Several interactions that occur between tumour necrosis factor (TNF) superfamily members have gained prominence based on studies of animal models of immune function and disease. The interactions ...

There have been important recent advances in the management of Crohn's disease, including new classes of biological or small molecule therapies, an appreciation that endoscopic mucosal healing results ...

The TNF receptor superfamily includes cytokines such as lymphotoxins, TNF- α and cellular ligands such as FasL (CD95) and CD40L. The latter mediates B cell and T cell activation while FasL ...

The pleiotropic cytokine of the tumor necrosis factor superfamily with the most attention is TNF-α. TNF-α is a crucial cytokine in the innate immune response that aids in direct host defense ...

Safety and efficacy of adoptive cell transfer using autologous tumor infiltrating lymphocytes (LN-145) for treatment of recurrent, metastatic, or persistent cervical carcinoma. This is an ASCO Meeting ...

Trophoblast cell-surface antigen 2 is a biomarker and potential therapeutic target in human colon cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not ...

BALTIMORE, April 16, 2025--(BUSINESS WIRE)--TNF Pharmaceuticals, Inc. (Nasdaq: TNFA) ("TNF" or the "Company"), a clinical stage biopharmaceutical company committed to ...

Exposure to antitumor necrosis factor (anti-TNF) therapy during the first 140 days of pregnancy is associated with a significant decrease in the risk of developing gestational diabetes (GD ...