Spider-Man 2099 introduced a second heroic age in a world ... until the introduction of Strange 2099. A young woman named Jeannie, Strange 2099, was the Sorcerer Supreme of her time.
The cyberpunk-esque 2099 timeline has many spiders around, including Spider-Man, Spidercide, and Spider-Woman, so this new take on Ghost-Spider is perfectly at home among her fellow arachnids.