Osteoporosis is the most common of all bone diseases and it has been called the silent killer because there are often no symptoms. Also osteoporosis can mimic other diseases such chronic fatigue ...

Bone tissue is composed of cells, namely osteoblasts, osteoclasts and osteocytes, and an extracellular matrix comprising inorganic hydroxyapatite crystals and organic collagen.

It relies on the coordinated activity of bone-resorbing osteoclasts and bone-forming osteoblasts, as well as osteocytes, which act as mechanosensors and regulators of local remodeling activity.

Comprehensive Orthopedics Department, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, P. R. China State Key Laboratory for Manufacturing Systems Engineering, Xi’an ...