A bone biopsy specimen revealed giant osteoclasts with more than 40 nuclear profiles. Investigations. Bone mineral density determinations, measurement of serum 25-hydroxyvitamin D, intact ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

Osteoclasts are specialized, multinucleated cells that play a vital role in bone development and regeneration. Credit: vetpathologist/Shutterstock.com The skeleton is ...

A protein has been identified that promotes the formation of osteoclasts, bone-degrading cells—while also inhibiting osteoblasts, bone-forming cells. The findings could lead to new avenues of ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients benefiting from therapy, little change, if any, has been observed in the number of osteoclasts ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Among those is a cell type called osteoclasts, which are specialized cells involved in breaking down bone tissue and served as the starting point for the researchers at the University of New South ...

A new discovery about osteoporosis suggests a potential treatment target for that brittle-bone disease and for bone loss from rheumatoid arthritis. A new discovery about osteoporosis suggests a ...

Recent data from Holliday and her team of researchers shows that extracellular vesicles (EVs) released by osteoclasts regulate bone cells in vitro. MicroRNAs are small, non-coding RNAs that ...

Researchers led by Kanazawa University show that messages sent by osteoblasts via extracellular vesicles trigger the formation of mature osteoclasts during fracture healing Kanazawa, Japan - In a ...