(ends) Abstract no: 12, “On-target mutations drive resistance to WRN helicase inhibitors in microsatellite unstable colorectal cancer”, by Gabriele Picco, presented in plenary session 7 ...

More information: Abstract no: 12, "On-target mutations drive resistance to WRN helicase inhibitors in microsatellite ...

Professor Yoon Jong-hyuk (Gastrointestinal Surgery) of Cheonan Hospital, affiliated with Soonchunhyang University, recently won the Excellence Researcher Awar ...

“Ultimately, if the tumor is microsatellite unstable, that always makes us question whether somebody was born with a genetic syndrome. They may or may not have been, but they should be tested. The ...

Most colorectal cancer (CRC) cases are secondary to an existing adenoma ... and were more likely to be poorly differentiated, microsatellite unstable, and KRAS-wild. Overall, adenocarcinoma arising ...

The FDA recently approved a phase 2 clinical trial to investigate the efficacy of leronlimab in patients with relapsed or ...

Microsatellite instability (MSI) is a “striking” prognostic factor for patients with gastric cancer, even after controlling for clinicopathologic characteristics, according to researchers. The ...

Although pembrolizumab is approved for deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors regardless of histology, there is a paucity of data to support its effectiveness ...

Nov. 4, 2024 — Researchers have uncovered new targets that could be the key to effectively treating glioblastoma, a lethal type of brain cancer. These targets were identified through a screen ...

Doctors were convinced that a Norwegian man was simply fat for 12 years — but his growing belly was actually expanding with a 60-pound malignant tumor. He was diagnosed with obesity and even got ...

The abnormal behaviour of cancer cells can thus be explained by invoking quantitative and/or qualitative changes in this active gene set. Sequence–based qualitative changes have received the ...