Ankyra Therapeutics is a biotech developing anchored immunotherapies aimed at enhancing the therapeutic window of ...

“The FDA’s decision to grant Fast Track designation for TEV-53408, an investigational anti-IL-15 antibody therapy, reflects the promising nature of the treatment and the urgent unmet need of people ...

Like Th1 and Th2 cells, Th17 cells produce a group of distinctive cytokines — interleukin-17 (also called interleukin-17A), interleukin-17F, interleukin-22, and interleukin-21 — all of which ...

Interleukin-2 (IL-2) and IL-15 have both similar and contrasting functional roles in the life and death of lymphocytes. The heterotrimeric receptors for these cytokines have two subunits in common ...

Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these ...

The results of the MIROCALS randomized clinical trial have shown that adding low-dose interleukin-2 (IL2LD) to standard treatment for amyotrophic lateral sclerosis slowed functional decline and ...

Why measure soluble interleukin-2 receptor levels? Interleukin-2 (IL-2) plays a crucial role as a signaling molecule in the human immune system. It belongs to a group of small, secreted proteins ...

Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

Low dose interleukin 2 is being tested as an immunomodulatory approach in neurodegenerative diseases. It increases the number and activity of regulatory T cells (Tregs) that suppress inflammation. At ...

Researchers at Duke-NUS Medical School in Singapore have previously undertaken three different studies to examine interleukin-11 (IL-11) protein expression and its role in heart and kidney ...

The team demonstrated in preclinical models that the protein interleukin-11 (IL-11) actively promotes aging and that giving an anti-IL-11 therapy not only counteracts the deleterious effects of ...

In the experiments, researchers used T cells of various genetic backgrounds and also used various biological inhibitors, such as antibodies against interleukins or against interleukin receptors.