This includes investigation of nuclear organization, DNA methylation, histone modification and ... SAGA complex and enhance nucleosome acetylation, promoting metabolic reprogramming and cell ...

This review highlights the critical role of epigenetic regulation in nuclear receptor function, shedding new light on its ...

Australian researchers have discovered that a single mutation in the DNA sequence for a methylation enzyme dysregulates key ...

(NEPC). The findings enhance the understanding of the treatment of androgen receptor functions in NEPC. Neuroendocrine prostate cancer (NEPC) arises primarily through neuroendocrine ...

Two closely related Arabidopsis RPD3-type histone deacetylases HDA19 and HDA6, exhibit functional divergence, yet the molecular mechanisms underlying this divergence remain largely unclear. This study ...

RNA sequencing identified HIC1 (hypermethylated in cancer 1) as a novel target for Suv39h1. HIC1 expression was repressed by Suv39h1 during VSMC phenotypic modulation, whereas HIC1 overexpression ...