Harrelson, this weekend's host for Saturday Night Live, starred in the most absurd spoof commercial yet this season, as the actor fends off deviant Cologuard boxes who want him to "unleash" inside ...

But at the end of the day… it’s still pooping in a box, and the company that makes Cologuard (it’s an actual thing, not made up like Bass-O-Matic or Colon Blow) sells it with a cheerful ...

The test kit arrives at the castle’s front doors and is placed by a chamber pot, after which Little C.G., Exact’s anthropomorphic Cologuard box mascot, is knighted by the grateful king.

Even before the current campaign, however, Cologuard had already entered into pop culture through its popular animated box, according to Nanda. “He’s our best friend,” she says.

The Cologuard Plus test demonstrated 95% sensitivity for colorectal cancer detection at 94% specificity, making it the most accurate noninvasive CRC screening test reported in studies to date ...