eLife22d
Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
We further explored the TRPV1 and DPP3 to detect the potential off-target effects of CAP respectively. Capsazepine (CAPZ), which is TRPV1 receptor antagonist did not affect the protection of CAP ...
C&EN19d
Noninvasive Vagus Nerve Electrical Stimulation for Immune Modulation in Sepsis Therapy
Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Sepsis presents a significant medical challenge due to its intense inflammatory ...
Frontiers16d
Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1
Kirsehir Ahi Evran University Medicine Faculty Department of Physiology, Kirsehir, Türkiye Control (n = 10): The rats underwent no drug treatment, being administered 1 mL of 5% dextrose ...
Frontiers20d
TRP Channels Regulation of Rho GTPases in Brain Context and Diseases
Figure 1. Cyclic Rho GTPase modulation, functions, and TRP channel-mediated regulation hypothesis. Rho GTPases cycle between an active form bound to GTP (blue arrows) and an inactive form that is ...
C&EN12d
Highly Specific Miniaturized Fluorescent Monoacylglycerol Lipase Probes Enable Translational Research
Leibniz Forschungsinstitut für Molekulare Pharmakologie, Campus Berlin-Buch, 13125 Berlin, Germany ...