Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 ...

Objectives To evaluate the time course of clinical response following anifrolumab treatment in patients with SLE. Methods A post hoc analysis was conducted using pooled data from phase III, randomised ...

Objectives The lupus low disease activity state (LLDAS) allows for certain clinical and/or serological activity of SLE, provided overall disease activity does not exceed predefined cut-offs. This ...

1 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Institute of Chinese Medicine, Beijing, China Objective Celastrol is a bioactive constituent extracted from ...

Objectives Cardiovascular disease (CVD) is a leading cause of death in SLE. Coronary artery calcium (CAC) scores predict CVD events, independent of traditional risk factors. Patients with SLE aged >45 ...

1 Laboratory of Thromboinflammation, Nasonova Research Institute of Rheumatology, Russian Federation 2 Laboratories of biomedical research methods, Moscow Regional Clinical Research Institute named ...

We will not keep your email address; we ask for it so your friend knows the email isn't spam.

Background Single-cell RNA-Seq (scRNA-seq) has the potential to increase our understanding of cell populations in lupus. Recently, kidney scRNA-Seq data from lupus nephritis (LN) patients has provided ...

Background As the prototype of autoimmune disease, systemic lupus erythematosus (SLE) has complex and diverse clinical manifestations which may be harmful even life-threaten. Its pitiful that we can ...

Background Rituximab is associated with high infection rates, but studies of infections following rituximab in youth with childhood-onset SLE (cSLE) are limited. We conducted a retrospective ...

Purpose Peptidylarginine deiminase (PAD) 1–4 and PAD6 are responsible for protein citrullination. PAD4 is highly expressed in neutrophils and is essential for NETosis, which has been implicated in the ...