Ischemic stroke in younger adults is far less common than that among older adults, yet the underlying pathogeneses and risk factors are more diverse. Approximately 10% to 15% of all strokes occur in ...

Rationale:Recent evidence indicates that a few human microRNAs (miRNAs), in particular hsa-miR-199a-3p and hsa-miR-590-3p, stimulate proliferation of cardiomyocytes and, once expressed in the mouse ...

Figure 1. Invasive cardiopulmonary exercise test results. A, Analysis of the case vignette patient’s key functional performance measures demonstrates that the maximum respiratory exchange ratio, which ...

The prognostic role and the clinical significance of orthostatic hypertension (OHT) remained undefined for long because data were sparse and often inconsistent. In recent years, evidence has been ...

Background— The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique opportunities for basic and ...

Statins are powerful lipid-lowering drugs that inhibit cholesterol biosynthesis via downregulation of hydroxymethylglutaryl coenzyme-A reductase. 1 They are largely used in patients with or at risk of ...

In keeping with the scope of the Journal, we hope that many Viewpoints will contain insights from the patient’s perspective along with suggestions on how to improve clinical care and healthcare ...

Smooth muscle cell migration occurs during vascular development, in response to vascular injury, and during atherogenesis. Many proximal signals and signal transduction pathways activated during ...

In contrast to therapeutic trial results, observational data from the National Health and Nutrition Survey (NHANES) have predicted a relatively lower prevalence of resistant hypertension. Analyzing ...

More than 400 million years ago, renin first appeared in organisms, 3 and renin is often seen as the first hormone discovered. Shortly before the 20th century, Tigerstedt and Bergman showed that ...

Background—MicroRNAs (miRs) are small noncoding RNAs that posttranscriptionally control gene expression. Small-animal studies suggest that miRs might offer novel therapeutic targets in cardiovascular ...

Previous clinical studies have reached a similar conclusion with regard to the predominance of Th1-type immune responses in graft arteriosclerosis by analyzing patient samples other than diseased ...