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Itanium came out before AMD's x86-64 instruction set and, thus, did not rely on the x86 instruction set. Itanium relied on what's known as the IA-64 architecture, a Very Long Instruction Word ...
The chip titan proposed last year that it was about time to introduce a slimmed-down, 64-bit-only version of the x86 architecture, which Intel created alongside the famous 8086 chip back in the 1970s.