Cost is a major obstacle for many. The drugs can be expensive without insurance, with out-of-pocket expenses reaching hundreds of dollars per prescription. The poll found that about half of Americans support Medicare and Medicaid covering weight-loss drugs for those with obesity, while around 20 percent oppose it and 25 percent are neutral.

There’s an obesity epidemic and we feel we can bring a ton of awareness to people through the Super Bowl,” said Dan Kenger, chief design officer at Hims & Hers. “There are very few live TV events that we as America all come around and congregate for and this provides a good platform to get that message out there.

Telehealth company's spot decries medications from others as "priced for profits, not patients," while its own weight-loss drugs are "affordable."