(A) The microenvironment is composed of blood and lymphatic ... of a tissue and accumulated within solid structural components (ie, cancer and stromal cells, collagen, and hyaluronan) during growth ...

Patients were required to have hyaluronan-high tumors, defined as ≥ 50% hyaluronan staining in the ECM of tumor samples, which were analyzed centrally with a hyaluronan affinity histochemistry assay ...

Amidst the continued struggle to treat non-small-cell lung cancer, a new study led by Stanford University scientists suggests that a patient's response to immunotherapy may hinge on how immune cells ...

To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

Cancer cells acidify the microenvironment and deplete nutrients and oxygen, impairing the function of CD8+ T cells and preventing their cytotoxic effects against cancer cells. JHU083 elicited ...

Tumor cells live within a specific tumor microenvironment, in which they are surrounded by other cell types, including those comprising blood vessels, cancer-associated fibroblasts (CAFs ...

Interestingly, these processes are all sensitive to the concentration of oxygen present in the microenvironment. Rapidly proliferating cells cause the NSCLC tumor to extend beyond the oxygen ...

Their role in shaping the complex interactions between cancer cells and their microenvironment makes them vital for sustaining tumor development. Additionally, lncRNAs regulate processes such as ...

Tumors are not just isolated clumps of abnormal cells but are associated with more complex system known as the “tumor microenvironment” (TME). Over the past few years, research has revealed ...

fueled a myeloid-rich tumor microenvironment in mice, and resulted in the promotion of tumor organoid growth. TI-CH increased the risk of disease recurrence or death among patients with NSCLC and ...