COPII may be partially retained on the membrane until vesicles are tethered, playing an essential role in post-budding events (see below) 19,20. Upon coat depolymerization, COPII proteins are ...

Lipids control the release of active SREBP by regulating the access of the precursor protein, which is located in the endoplasmic reticulum (ER), to the proteases, S1P and S2P, which are found in ...

In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis ...