Notch, ErbB4 and Ire1p, within their hydrophobic transmembrane domains represents a novel form of regulated intramembranous proteolysis similar to that which cleaves SREBP (sterol-regulatory ...

Medific Inc. has described substituted thiazolidinedione derivatives acting as sterol regulatory element binding protein (SREBP; SREBF1) inhibitors reported to be useful for the treatment of cancer, ...

In a recent study, researchers identified a novel cleavage enzyme of SREBP-1c, a key player in fatty acid biosynthesis. Moreover, the team unveiled, for the first time, that the biosynthesis ...

Activation of Notch signaling pathologically enhances lipogenesis ... of AMPK and ACC and suppressed nuclear expression of SREBP-1c in the mouse liver or hepatocytes, indicating regulation of ...