A bone biopsy specimen revealed giant osteoclasts with more than 40 nuclear profiles. Investigations. Bone mineral density determinations, measurement of serum 25-hydroxyvitamin D, intact ...

Osteoclasts are specialized, multinucleated cells that play a vital role in bone development and regeneration. Credit: vetpathologist/Shutterstock.com The skeleton is ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

Osteoclasts, the bone-resorbing cells, play a pivotal role in skeletal development and adult bone remodeling. They also participate in the pathogenesis of various bone disorders. Osteoclasts ...

Bone-destructive diseases such as osteoporosis and chronic inflammatory arthritis affect millions of people worldwide, ...

Researchers have developed a novel compound that could be useful for treating bone-destructive diseases. Their study ...

Bone-dissolving cells called osteoclasts are derived from a type of immune cells called macrophages. They are necessary for the maintenance and renewal of bones. But the intracellular mechanisms ...

However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients benefiting from therapy, little change, if any, has been observed in the number of osteoclasts ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Among those is a cell type called osteoclasts, which are specialized cells involved in breaking down bone tissue and served as the starting point for the researchers at the University of New South ...

Excessive activity of 'osteoclasts' or bone-absorbing cells leads to bone loss. Targeting osteoclast differentiation is therefore, a potential therapeutic strategy. In a new study, researchers ...

The most commonly used osteoporosis therapies (bisphosphonates) target osteoclasts to prevent further bone loss. Although there are new 'anabolic' agents that can promote new bone formation ...