Osteoblasts are the cells required for bone synthesis and mineralization, both during the initial formation of bone and during bone remodelling. These cells are present on the bone surface in the ...

The tropism of prostate cancer cells for bone and their tendency to induce the osteoblastic phenotype is a result of interactions between prostate cancer cells and osteoblasts. Prostate cancer ...

Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an ...

Panel A shows osteoclasts and osteoblasts in normal bone (toluidine blue, ×100). The large osteoclast is actively resorbing bone. Osteoblasts are small, cuboid cells that actively lay down bone ...

Researchers show that intercellular communication via extracellular vesicles from bone-making osteoblasts is a key factor for this switch through a microRNA-mediated mechanism. Bone remodeling ...

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers has now identified an enzyme that controls the activity of osteoblasts.

In the study, the researchers conducted biofunctionalization experiments with murine calvariae pre-osteoblasts (MC3T3-E1) to assess the osteogenic response on modified 3-D surfaces for BTE.

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University ...

Bone is constantly formed, reformed, and remodeled throughout life, and up to 10% of human bone is replaced annually through a complex interplay between two cell types—osteoblasts, which form ...

However, recent evidence also points to a direct action of bisphosphonates on bone-forming osteoblasts. Despite its clinical importance, the mechanisms of BPs on osteoblast function still remain ...

The disease occurs when there's an imbalance between a person's osteoblasts – which are bone-building cells – and their osteoclasts, which are bone-degrading cells. Ordinarily, osteoclasts ...

9 Not only is the balance of osteoblasts and osteoclasts altered, but the microenvironment of the osteocyte is also remodeled, leading to the increased apoptosis of osteocytes. Testosterone plays ...