The protein—a cell receptor called NOD2 found in several types of immune cells—has long been known for its role in fighting off bacterial invaders by sensing their presence and alerting immune ...

APCs can digest the TLR2 ligand bacterial PGN and generate the PGN component MDP, a specific agonist for NOD2 (refs. 9,10). This suggests that PGN can stimulate cells through both cell surface ...

IRF3 denotes interferon regulatory factor 3, NF-κB nuclear factor-κB, NOD2 NOD-containing receptor 2, RIP2 receptor-interacting protein 2, and SYK spleen tyrosine kinase. In 2007, Casanova and ...

During its investigations, the team of researchers at TUM focused on a protein called NOD2. This receptor of the immune system is able to "recognize" intestinal bacteria -- or more precisely ...

The pathway is also activated by NOD2 (also referred to as CARD 15), an intracytoplasmic receptor that is activated by the entry, through mechanisms yet to be defined, of bacterial ...