It is well established that polymorphisms of the caspase activation and recruitment domain 15 (CARD15) gene, a major risk factor in Crohn’s disease (CD), lead to loss of nucleotide-binding ...

Accumulating evidence implicates defective innate immunity in the pathogenesis of Crohn’s disease (CD). Ineffectual NOD2 (nucleotide-binding oligomerization domain 2) is the most common ...

NOD2 mutations: Genetic analysis for NOD2 mutations may be predictive of fibrostenotic disease in CD, though it is not specific for treatment response. Anti-Integrin αvβ6: Blood levels of anti ...

The research began by investigating a type of receptor called NOD2 (nucleotide oligomerization domain). These receptors are generally found on certain immune cells and they respond to the presence ...