Notch signaling and epithelial-to-mesenchymal transition (EMT). Transformed, recruited and differentially activated cells surrounding the tumor form the tumor microenvironment. These cells inhibit ...

To effectively battle cancer, scientists must study the battlefield. Now, in a recent study published in Nature ...

The tumor microenvironment (TME ... in TAFs has been linked to enhanced migration and invasiveness of ovarian epithelial carcinoma cells. TAFs are also involved in the development of therapy ...

IMUNON’s Phase 2 OVATION 2 trial of IMNN-001 in advanced ovarian cancer showed a 13-month OS increase (46 vs. 33 months) and ...

“Anti-tumor immune cells are also challenged by nutrient limitation in tumors.” Nutrient limitation in the tumor microenvironment can lead to the metabolic suppression of effector immune cells, ...

This innovative model not only simulates the tumor microenvironment but also integrates artificial intelligence (AI) technology that can predict patient prognosis solely from images of tumor growth.

fueled a myeloid-rich tumor microenvironment in mice, and resulted in the promotion of tumor organoid growth. TI-CH increased the risk of disease recurrence or death among patients with NSCLC and ...

The tumor microenvironment—the complex environment that surrounds cancer cells—is often deprived of nutrients and oxygen, particularly in hard-to-treat cancers like pancreatic cancer.

describe a thymic epithelial cell subpopulation that can fully reconstitute the complex thymic epithelial microenvironment (Nat Immunol 2002, DOI:10.1038/ni812). Gill et al. used murine embryos at ...