The paper B.W. Bauer et al., “Cohesin mediates DNA loop extrusion by a ‘swing and clamp’ mechanism,” Cell, 184:5448–64, 2021. Approximately 2 meters of DNA is crammed into each of the human body’s ...

If cohesin rings actually worked that way ... Real-Time Imaging of DNA Loop Extrusion by Condensin. Mahipal Ganji et al. in Science, Vol. 360, pages 102-105; April 6, 2018. The Inner Life of ...

And strikingly, the team found that it did: the human SMC protein cohesin does indeed ... same amount of twist—they turn DNA 0.6 times at every DNA loop extrusion step. This shows that the ...

However, this loop extrusion hypothesis was too radically different from the established view of DNA being static and cohesin forming passive rings around it and was therefore received with ...

The illustration shows DNA being folded into a loop by an SMC motor called cohesin (in purple/blue). The purple part of the motor (with a red/green label) is the protein subunit NIPBL, which acts ...

The Structural Maintenance of Chromosomes (SMC) protein complexes condensin, cohesin and Smc5/6 play a central role ... Two of them inhibit the formation of Smc5/6 dimers and, thus, regulate DNA-loop ...

It is one of the mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter ... One problem with this loop extrusion model was that, up until now, a motor ...

And strikingly, the team found that it did: the human SMC protein cohesin does indeed ... amount of twist -- they turn DNA 0.6 times at every at every DNA loop extrusion step.