“Cohesin mediates DNA loop extrusion by a ‘swing and clamp’ mechanism ... To achieve this packaging feat, DNA is wrapped around proteins to make chromatin fibers, and further condensed into tightly ...

When they compared protein expression between neutrophils and their progenitors, one protein caught their attention: loop-extrusion loading factor nipped-B-like protein (NIPBL). This factor, which ...

Grappling motors bring distant segments of chromatin fibers together ... description that predicts the spatial distribution of loop extrusion probabilities. This model resolved how the motors ...