The diagnosis of medulloblastoma was histologically ... according to the tumor staging system of Chang and colleagues. 18 In this system, stage M1 denotes disseminated tumor cells in the ...

Criteria used to categorize patients as high risk included M1-4 disease by modified Chang staging classification, T3b/T4 disease, or greater than 1.5 cm 3 of residual tumor after surgery.

Diagnosis of medulloblastoma (classic or desmoplastic ... and 33 ±14% and 38 ± 15% for those who had disseminated disease (Chang stage M2 or M3). Overall response rate to chemotherapy was ...

Studies of murine models suggest that aberrant granule-cell development might result in a subset of medulloblastoma tumors; recently identified cerebellar neural stem cells might be another ...

Medulloblastoma is the most common malignant brain tumor in children. Aberrant activation of the hedgehog signaling pathway is strongly implicated in the development of some cases of medulloblastoma.

A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models -- all without showing signs of toxicity. A drug ...

For the purposes of this study, patients with medulloblastoma were considered high risk if they had M1-4 disease by modified Chang staging classification, exhibited T3b/T4 disease at time of surgery, ...

Medulloblastoma is the most common brain malignancy in children and tremendous advances have recently been made in understanding the pathogenesis of this tumor. The Hedgehog and Wingless signaling ...