Sen argues that “erosion of the epigenome” at cryptic sites associated with aging in senescent cells could boost spurious transcription. Although histone methylation decreased overall in senescent ...

The variety of blood cells decreases with age. Some are lost, while others become dominant, leading to a loss of functional ...

1 Aging is accompanied by progressive epigenetic drift — a divergence from the original epigenomic configuration of a young cell. This includes aberrant DNA methylation, histone modifications ...

Vitamin D supplements may help prevent the loss of telomeres, DNA sequences that shrink with aging, a large study shows. But ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding ... models across tissues and cell types. Aging involves complex cellular ...

2 The collection of epigenetic marks in a cell or organism is known as its epigenome ... the most established and well-researched of which are histone modifications and DNA methylation. “What's ...

So underlying a great deal of modern anti-aging research is the quest to reverse, or remove, these age-related methylation markers. If we could scrub a cell clean of these marks then in theory we ...

They found that transcripts are less methylated in microglia than in other cells, that methylation patterns distinguish neuronal subtypes, and that, for thousands of transcripts, including some linked ...