Additional information reveals that molecular side chains attached to the beta-lactam ring are more likely to be responsible for shared antigenic capability. Recent literature now suggests that ...

In 1928, Sir Alexander Fleming discovered that the active component of a penicillium fungus had the capacity to kill bacteria in a petri dish, and he named it penicillin. In 1945, Fleming, Florey ...

The addition of an isoxazolyl side chain to the penicillin compound blocks the acid hydrolysis of the beta-lactam ring by penicillinases produced by the species of the genus Staphylococcus.

Cephalosporin allergies have largely been attributed to an antigenic response to the R1 or R2 side chains rather than the core beta-lactam portion of the molecule. Aminopenicillins such as ...

Beta-lactam antibiotics are the most commonly ... penicillins is produced by altering the composition of the side chains attached to this nucleus. Powerful electron-attracting groups attached ...

Full-dose challenges for emergency department (ED) patients with moderate, severe, and unknown beta-lactam allergies can safely reduce unnecessary antibiotic regimens, cut costs, and preserve ...

SAN DIEGO—For uncomplicated Gram-negative bloodstream infections, oral beta-lactam therapy may be an appropriate stepdown option, with fewer side effects, compared to fluoroquinolones.