These studies have led to the identification of components of the mTOR signaling pathway, the autophagy pathway, and transcriptional regulators of metabolism, all as direct substrates of AMPK. In ...

Depression is one of the most common and disabling mental health conditions in the world, affecting over 10% of people ...

while acute stress activated AMPK signaling, which promotes it. These pathways operate independently. Systemic treatment with antidepressants increased autophagy activity in the lateral habenula.

is enhanced by IF through the activation of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK) and sirtuin 1 (SIRT1) signaling pathways. This process effectively clears damaged cellular ...