Avezzano is a city in the Abruzzo region, province of L'Aquila, Italy. It is the second most populous municipality in the province and the sixth i…Avezzano is a city in the Abruzzo region, province of L'Aquila, Italy. It is the second most populous municipality in the province and the sixth in the region. It is the main commercial, industrial and agricultural centre of the Marsica area, with important high-tech industries and the Fucino Space Centre.