SLC Transporters: Structure, Function, and Drug Discovery
WEBJun 1, 2016 · In this review, we provide an overview of the SLC transporters’ structures and transport mechanisms. We then describe computational techniques, such as homology modeling and virtual screening that are emerging as key tools to discover chemical probes for human SLC members.
The SLC transporter in nutrient and metabolic sensing, …
WEBSep 18, 2018 · We aim to understand the molecular mechanisms of important SLC transporter-mediated physiological processes and their potentials as drug targets. SLC transporters serve as ‘metabolic gate’ of cells and mediate the transport of a wide range of essential nutrients and metabolites such as glucose, amino acids, vitamins, neurotransmitters, and ...
Solute Carrier (SLC) Transporters: An Overview | SpringerLink
WEBSep 12, 2021 · The SLC transporter superfamily comprises more than 400 membrane-bound proteins that facilitate the transport of a wide range of substrates – including endogenous molecules, nutrients, and xenobiotics (among them drugs) – …
Solute carrier transporters: the metabolic gatekeepers of immune …
WEBDec 14, 2019 · Solute carrier (SLC) transporters meditate many essential physiological functions, including nutrient uptake, ion influx/efflux, and waste disposal.
Targeting SLC transporters: small molecules as modulators and ...
WEBJun 22, 2023 · Solute carrier (SLCs) transporters mediate the transport of a broad range of solutes across biological membranes. Dysregulation of SLCs has been associated with various pathologies, including metabolic and neurological disorders, as well …
A widespread role for SLC transmembrane transporters in ... - Nature
WEBMar 9, 2020 · Solute carriers (SLCs) are the largest family of transmembrane transporters in humans and are major determinants of cellular metabolism. Several SLCs have been shown to be required for the...
WEBThe solute carrier (SLC) superfamily is one of the two main superfamilies of transporters, along with the ATP-binding cassette (ABC) superfamily. However, while ABC transporters function as ef ux transporters in eukaryotes (primary active. fl.
SLC transporters as therapeutic targets: emerging opportunities
WEBJun 26, 2015 · This study uses virtual screening against a comparative model of an SLC transporter to identify prescription drugs that may interact with the transporter.
SLC transporters: structure, function, and drug discovery
WEBIn this review, we provide an overview of the SLC transporters' structures and transport mechanisms. We then describe computational techniques, such as homology modeling and virtual screening that are emerging as key tools to …
SLC Transporters: Structure, Function, and Drug Discovery
WEBMar 28, 2016 · The human Solute Carrier (SLC) transporters are important targets for drug development. Structure-based drug discovery for SLC transporters requires the description of their structure,...