Partition coefficient - Wikipedia
WEBThe distribution coefficient, log D, is the ratio of the sum of the concentrations of all forms of the compound (ionized plus un-ionized) in each of the two phases, one essentially always aqueous; as such, it depends on the pH of the aqueous phase, and log D = log P for non-ionizable compounds at any pH.
Why LogD Matters / ΔLogD Cheat Sheet - Drug Hunter
WEBJan 10, 2020 · Here is a LogD cheat sheet created from their work, summarizing how much affinity is expected from a change based on lipophilicity considerations alone. For a methyl group for example, the median LogD change is about 0.3, indicating that you'd expect about a 2-fold increase in lipophilic potency due to the methyl group's contribution to LogD.
Logarithmic scale - Wikipedia
WEBA logarithmic scale (or log scale) is a method used to display numerical data that spans a broad range of values, especially when there are significant differences between the magnitudes of the numbers involved.
Logarithm - Wikipedia
WEBIn chemistry, pH is a logarithmic measure for the acidity of an aqueous solution. Logarithms are commonplace in scientific formulae, and in measurements of the complexity of algorithms and of geometric objects called fractals.
LogP vs LogD - What is the Difference? - ACD/Labs
WEBNov 16, 2023 · Unlike logP, which is pH-independent, the distribution coefficient, logD, changes with pH as its calculations account for all forms of a compound at a specific pH, including ionized, partially ionized, and unionized species.
Unit 8: Logarithms - Khan Academy
WEBAlgebra 2 12 units · 113 skills. Unit 1 Polynomial arithmetic. Unit 2 Complex numbers. Unit 3 Polynomial factorization. Unit 4 Polynomial division. Unit 5 Polynomial graphs. Unit 6 Rational exponents and radicals. Unit 7 Exponential models. Unit 8 Logarithms.
LogP and logD calculations - ChemAxon DOCS
WEBThis background material explains the theory behind the log P and log D calculation: Introduction. Symbols used. Definition of logP and logD. Example. Partition and distribution coefficients. Relation between macro and micro partition coefficients. LogP calculation methods. Examples for logP and logD calculations.
7.4: Properties of the Logarithm - Mathematics LibreTexts
WEBOct 6, 2021 · Since the natural logarithm is a base- e logarithm, \ln x=\log _ {e} x, all of the properties of the logarithm apply to it. We can use the properties of the logarithm to expand logarithmic expressions using sums, differences, and coefficients.
LogD - Cambridge MedChem Consulting
WEBJan 12, 2019 · Of particular interest is the log D at pH = 7.4 (the physiological pH of blood serum). Applications like Marvin allow the user to calculate the logD but also display the pH distribution profile, as shown below for Warfarin.
Logarithm Rules - ChiliMath
WEBLearn the eight (8) log rules or laws to help you evaluate, expand, condense, and solve logarithmic equations. Try out the log rules practice problems for an even better understanding.
- Some results have been removed
Skip to content